ForumTotal.com > Science & Education > Artificial Intelligence in Science > How can diffusion models design truly novel protein folds with limited data?
I've been following all the fashion weeks and designer previews, and I'm really excited about what's coming for 2025. From what I've seen, there are some really interesting fashion trends 2025 emerging that feel fresh but also wearable.
I'm particularly interested in the latest fashion trends that are hitting the runways. Some designers are bringing back certain silhouettes while others are experimenting with new fabrics and textures.
What do you all think will be the biggest trends? And more importantly, which ones are actually practical for everyday outfit inspiration?
I've been keeping an eye on the sustainable angle of fashion trends 2025, and I'm really excited about the increased focus on natural fabrics and recycled materials. Some designers are doing amazing things with organic cotton and regenerated fibers.
For everyday outfit inspiration, I think the relaxed tailoring trend is going to be huge. It's comfortable but still looks put together, which is perfect for those of us who want style without sacrificing comfort.
What I'm most interested in though is how these trends translate to actual wearable pieces. Some runway looks are beautiful but not practical for daily life.
From an accessories perspective, I'm seeing a lot of bold jewelry making a comeback. Chunky chains, statement earrings, and layered necklaces seem to be everywhere in the latest fashion trends.
I also think bags are getting more interesting - shapes that aren't just rectangular, materials that have texture, and colors that pop. These can really elevate even the simplest casual outfit ideas.
The key with accessories is balancing trend pieces with classics. You don't want to invest in something that will look dated in six months, but a few fun pieces can update your whole look.
For men's fashion, I'm noticing a shift toward more expressive pieces while still maintaining functionality. The fashion trends 2025 seem to be embracing color and pattern in menswear more than we've seen in recent years.
What's practical though are the updated basics. Better fitting t-shirts, trousers with interesting details, and outerwear that actually has style. These are the pieces that can form the foundation of great everyday outfit inspiration.
I think the biggest challenge for men is figuring out which trends to adopt and which to skip. Not everything that works on the runway works in real life.
What's interesting to me is how many fashion trends 2025 are actually reinterpretations of vintage styles. I've been seeing a lot of 70s and 90s influences in the latest fashion trends, which makes it easier for those of us who love vintage fashion ideas.
The key is taking the essence of the trend rather than copying it exactly. For example, wide leg trousers are back, but the fabrics and cuts are updated for modern comfort and movement.
I think street style inspiration is really helpful for seeing how real people are wearing these trends. It's less about the runway fantasy and more about what actually works for daily life.
As someone who prefers a minimalist approach, I'm looking at fashion trends 2025 through a different lens. I want to know which trends have staying power versus which are just flashes in the pan.
For minimalist fashion tips, I focus on silhouette and fabric rather than specific prints or colors. If a trend introduces a new shape that's flattering and functional, that's worth considering. But if it's just a loud pattern that will look dated next season, I skip it.
The best everyday outfit inspiration comes from pieces that work hard in your wardrobe. Trends that add versatility rather than just novelty are the ones worth investing in.
I've been trying to use a diffusion model to generate plausible initial structures for a novel protein fold I'm theorizing, but the outputs keep converging on known architectures. My training data is necessarily limited to existing protein databases, so I'm worried the model is just remixing patterns and can't truly propose a structurally sound novelty. Has anyone else hit this fundamental data limitation when using generative models for de novo design?
I tried a diffusion model pipeline and I swear every batch drifted back to known folds. It felt like the model was remixing old patterns no matter how I reshuffled the data.
Bias in the training set was obvious. I added random decoys and non foldable peptides to try to break the hook, and I tracked how often outputs landed in a known class by clustering the generated structures and comparing to PDB labels.
Maybe the bottleneck isn't the data so much as how we encode constraints. Is there a way to test if the representation itself is steering you toward familiar architectures?
I tried post generation physics refinement on a subset and it did punch up the plausibility a bit, but the shapes still sat in the same few clusters after refinement.